What is Akkermansia Muciniphila and why is it in the Essential Microbiome?Updated 2 hours ago

Unlike more common strains like Lactobacillus or Bifidobacterium, Akkermansia is a keystone species found in the mucus layer of healthy guts. Its presence is strongly correlated with better metabolic health, improved inflammatory response, and a more resilient gut barrier.

• Clinically validated in humans: In a randomized controlled trial in overweight and insulin-resistant adults, daily supplementation with pasteurized Akkermansia for three months improved insulin sensitivity by 28.6%, reduced fasting insulin by 34%, and reduced total cholesterol by 8.7% compared to placebo.
• Pasteurized form of Akkermansia outperforms live strains: Heat-treated Akkermansia (like ours) was more efficient than live cells (like competitors') at improving metabolic markers, inflammation, and liver dysfunction in both humans and mice.
• Repairs gut lining: Via the outer membrane protein Amuc_1100, Akkermansia enhances mucus thickness and tight junction integrity, reducing intestinal permeability.
• Modulates appetite and glucose: Influences gut hormones like GLP-1 and PPY, with downstream effects on gut-briand axis and glucose regulation.